ABSTRACT
@#Objective To explore the design of word-picture matching semantic judgment task based on Chinese high frequency nouns and further explore the way to apply the task in a functional magnetic resonance imaging (fMRI)/event-related potential (ERP) study.Methods The materials, stimuli and procedure of the word-picture matching semantic task were provided. Then, a healthy subject for the pilot study was included. In the pilot study, fMRI and ERP data of the subject were collected during the word-picture matching task. The fMRI and ERP data were analyzed to test the feasibility of the word-picture matching task in an fMRI/ERP task.Results The results of fMRI analysis showed an increased activity in the right middle frontal gyrus under the word-picture presenting condition compared with the "+" presenting condition. In addition, fMRI analysis showed an increased activity in the right middle temporal gyrus in the word-picture mismatching condition compared with the word-picture matching condition. The results of ERP analysis showed an increased activity in the left frontal/temporal area in the word-picture matching condition and an increased activity in the right frontal area in the word-picture mismatching condition.Conclusion Language associated brain regions can be identified in the fMRI/ERP research based on the word-picture matching task described in this article, which indicated that the task is effective in exploring language processing mechanism in the brain.
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@#Objective To explore the changes of resting state default mode network (DMN) in patients with chronic pain caused by cervical spondylosis (CPCS). Methods 8 healthy controls and 10 patients accepted functional MRI scanning. Surface based DMN was extracted with independent component analysis (ICA). The functional connectivity of the components of DMN were discriminated with support vector machine (SVM) algorithm from the patients to the controls. Results The DMN connectivity was different in the patients from the controls in some of the component areas. Conclusion DMN of CPCS patients is disorder in multiple brain areas, which may be involved with dysfunction of perception processing, emotion and memory.
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Objective To explore the changes of resting state default mode network (DMN) in patients with chronic pain caused by cer-vical spondylosis (CPCS). Methods 8 healthy controls and 10 patients accepted functional MRI scanning. Surface based DMN was extract-ed with independent component analysis (ICA). The functional connectivity of the components of DMN were discriminated with support vector machine (SVM) algorithm from the patients to the controls. Results The DMN connectivity was different in the patients from the con-trols in some of the component areas. Conclusion DMN of CPCS patients is disorder in multiple brain areas, which may be involved with dysfunction of perception processing, emotion and memory.
ABSTRACT
Objective To explore the effect of acupuncture at Yanglingquan (GB 34) on white matter structure of stroke patients. Meth-ods 6 stroke patients with left hemiplegia in recovery stage were recruited. The sham acupoint was as control, the diffusion tensor imaging (DTI) data in a 1.5 T SIEMENS scanner before and after acupuncture at Yanglingquan point was collected. Differences between the two con-ditions were compared with the Tract-Based Spatial Statistics (TBSS), which is one of FSL tools. Results The brain areas included left pre-central gyrus, postcentral gyrus, middle temporal gyrus, inferior temporal gyrus, supplementary motor area, inferior frontal gyrus, internal capsule, fornix and bilateral inferior parietal gyrus, in which the verum acupuncture had stronger effect on fractional anisotropy (FA) than the sham acupuncture. White matter tract such as pyramidal tract, arcuate fasciculus, corpus callosum and other inter-cortex association fi-bers passed these brain areas. The fiber tracts and brain areas were found to be involved with multiple brain networks of motor compensa-tion, somatosensory, language and cognition. Conclusion Compared with the sham point, acupuncture at Yanglingquan point can change the microstructure of stroke patients' white matter, mainly in the inaffected side and related to multiple functional networks.